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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

ABSTRACT: Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

PROVIDER: PRJNA616044 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11442758_1.fastq.gz	Fastqsanger.gz
	SRR11442758_2.fastq.gz	Fastqsanger.gz
	SRR11442759_1.fastq.gz	Fastqsanger.gz
	SRR11442759_2.fastq.gz	Fastqsanger.gz
	SRR11442760_1.fastq.gz	Fastqsanger.gz

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

Project description:Sall4 is among one of the most important reprogramming factors. However, the underline molecular mechanisms for such importance remains unclear. In this report, we first described the gene expression and chromatin accessibility dynamics in OKS-Sall4 induced somatic cell reprogramming, and screened a group of downstream targets of Sall4, among which, cecr2, regulated by Sall4 directly, can significantly promote OKS induced reprogramming. Moreover, Cecr2 and Sall4 shared several downstream targets, such as Esrrb, Nanog, T etc., at transcription level when overexpress in the context of OKS induced reprogramming. We further showed that the DTT domain of cecr2 was responding to the reprogramming activity. Our findings provide a new important reprogramming factors and suggesting the cecr2-associted protein network may contributes to overcoming the epigenetic barriers in reprogramming.

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ATAC-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [ChIP-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

Project description:Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4 [RNA-seq]

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Cecr2 promotes somatic cell reprogramming as a downstream target of SALL4

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-23 | GSE147681 | GEO

CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses

Project description:Purpose: Metastasis are responsible for the most majority of cancer-related deaths due to the lack of effective targeted therapies. Therefore, specific targets which tackle that complex process are needed to improve the therapeutic outcomes of metastatic breast cancer. Methods: ATAC-Seq analysis of CECR2 knockout and control LM2 cells. Results: CECR2 knockout regulate chromatin accessibility of NF-kB target genes . Conclusions: Our work confirmed that CECR2 knockout attenuates chromatin accessibility at promoters or enhancers of the downstream NF-kB target genes.

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