Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cell Type-Specific Transcriptional Profiling of the Hepatic Fasting Response

ABSTRACT: We generated time-resolved profiles of fasting-induced changes in the gene landscapes of hepatocytes and liver macrophages using the INTACT methodology

ORGANISM(S): Mus musculus

PROVIDER: GSE147923 | GEO | 2022/01/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cell Type-Specific Genomic Profiling of the Hepatic Fasting Response

Project description:We generated time-resolved profiles of fasting-induced changes in the genomic landscapes of hepatocytes and liver macrophages using the INTACT methodology

2022-01-27 | GSE147922 | GEO

Hepatocyte-Specific Genomic Profiling of the Hepatic Fasting Response

Project description:We generated profiles of fasting-induced changes in the genomic landscapes of in vivo hepatocytes using the INTACT methodology.

2021-08-30 | GSE181937 | GEO

Hepatocyte-Specific Transcriptional Profiling of the Hepatic Fasting Response

Project description:We generated transcriptional profiles of fasting-induced changes of in vivo hepatocytes using the INTACT methodology.

2021-08-30 | GSE181940 | GEO

Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

Project description:Accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still largely unknown. Post-translational modification by the Small Ubiquitin-like Modifier (SUMO), allows for adynamic regulation of numerous processes including transcriptional reprograming. We demonstrate that specific SUMOylation of transcription factor Prox1 represents a nutrient-sensitive determinant of hepatic fasting metabolism. Prox1 was highly SUMOylated on lysine 556 in the liver of ad libitum and re-fed mice, while this modification was abolished upon fasting. In the context of diet-induced obesity, Prox1 SUMOylation became less sensitive to fasting cues. The hepatocyte-selective knock-in of a SUMOylation-deficient Prox1 mutant into mice fed a high-fat/high-fructose diet led to a reduction of systemic cholesterol levels, associated with the induction of liver bile acid detoxifying pathways during fasting. The generation of tools to maintain the nutrient-sensitive SUMO-switch on Prox1 may thus contribute to the development of “fasting-based” approaches for the preservation of metabolic health.

2023-10-24 | PXD041329 | Pride

Effects of extensive fasting on hepatic transcription

2009-11-23 | GSE13064 | GEO

Effects of extensive fasting on hepatic transcription

Project description:Temporally restricted feeding has a profound effect on the hepatic circadian clock. While the circadian clock is largely unaffected by by extensive fasting, many transcripts are known to be affected by a fasting paradigm. This dataset shows the effect of extensive fasting on dynamic gene expression in the liver C57/B6 mice were entrained to ad libitum feeding schedule for two weeks. They were then released into constant were food was withdrawn at CT16. On the second day in constant darkness tissue was collected at the indicated timepoints. Total RNA was extracted and 5ug of total RNA was used for the standard Affymetrix protocol of amplification, labeling and hybridization

2009-11-23 | E-GEOD-13064 | biostudies-arrayexpress

Cell Type-Resolved Transcriptional Profiling of NASH and liver fibrosis

Project description:We generated hepatocyte-specific profiles of the transcriptional landscapes during NASH progression using the INTACT methodology.

2021-07-01 | GSE162876 | GEO

Cell Type-Resolved Genomic Profiling of NASH and liver fibrosis

Project description:We generated hepatocyte-specific profiles of the genomic landscapes during NASH progression using the INTACT methodology

2021-07-01 | GSE162870 | GEO

Hepatocyte-Specific Transcriptional Profiling of the Hepatic Fasting Response

Project description:Hepatocyte-Specific Transcriptional Profiling of the Hepatic Fasting Response

| PRJNA753936 | ENA

Hepatocyte-Specific Genomic Profiling of the Hepatic Fasting Response

Project description:Hepatocyte-Specific Genomic Profiling of the Hepatic Fasting Response

| PRJNA753926 | ENA