Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Recurrent evolution of vertebrate transcription factors via transposase capture

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Myotis velifer

PROVIDER: GSE148789 | GEO | 2020/05/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Recurrent evolution of vertebrate transcription factors by transposase capture.

Project description:Genes with novel cellular functions may evolve through exon shuffling, which can assemble novel protein architectures. Here, we show that DNA transposons provide a recurrent supply of materials to assemble protein-coding genes through exon shuffling. We find that transposase domains have been captured-primarily via alternative splicing-to form fusion proteins at least 94 times independently over the course of ~350 million years of tetrapod evolution. We find an excess of transposase DNA binding domains fused to host regulatory domains, especially the Krüppel-associated box (KRAB) domain, and identify four independently evolved KRAB-transposase fusion proteins repressing gene expression in a sequence-specific fashion. The bat-specific KRABINER fusion protein binds its cognate transposons genome-wide and controls a network of genes and cis-regulatory elements. These results illustrate how a transcription factor and its binding sites can emerge.

| S-EPMC8186458 | biostudies-literature

Recurrent evolution of vertebrate transcription factors via transposase capture [ChIP-Seq]

Project description:How novel genes and cellular functions evolve is a central question in biology. Exon shuffling represents a potent mechanism to assemble new protein architectures. Here we show that DNA transposons, which are mobile and pervasive in genomes, have provided a recurrent supply of both exons and splice sites to assemble novel protein-coding genes in vertebrates. We find that transposase domains have been captured, primarily via alternative splicing, to form new fusion proteins at least 99 times independently over ~350 million years of tetrapod evolution. Evolution favors fusion of transposase DNA-binding domains to host regulatory domains, especially the Krüppel-associated Box (KRAB), suggesting transposase capture frequently yields new transcriptional repressors. Consistent with this model, we show that four KRAB-transposase fusion proteins born independently in different mammalian lineages repress gene expression in a sequence-specific fashion. Genetic knockout and rescue of the bat-specific KRABINER fusion protein in cell culture demonstrates that it binds its cognate transposons genome wide and controls a network of genes and cis-regulatory elements. Transposase capture is thus a powerful mechanism whereby transcription factors and their associated cis-regulatory networks can evolve by repurposing DNA transposon families, which provide both DNA binding domains and pre-existing genomic binding sites.

2020-05-08 | GSE148788 | GEO

Recurrent evolution of vertebrate transcription factors via transposase capture [PRO-Seq]

2020-05-08 | GSE148787 | GEO

Recurrent evolution of vertebrate transcription factors via transposase capture

Project description:Recurrent evolution of vertebrate transcription factors via transposase capture

| PRJNA625721 | ENA

Recurrent evolution of vertebrate transcription factors via transposase capture [PRO-Seq]

Project description:Recurrent evolution of vertebrate transcription factors via transposase capture [PRO-Seq]

| PRJNA625724 | ENA

Recurrent evolution of vertebrate transcription factors via transposase capture [ChIP-Seq]

Project description:Recurrent evolution of vertebrate transcription factors via transposase capture [ChIP-Seq]

| PRJNA625725 | ENA

Stepwise Neofunctionalization of c-Rel during Vertebrate Evolution

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-02 | GSE243012 | GEO

Transposase-derived transcription factors regulate light signaling in Arabidopsis.

Project description:Plants use light to optimize growth and development. The photoreceptor phytochrome A (phyA) mediates various far-red light-induced responses. We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.

| S-EPMC2151751 | biostudies-literature

Evolution of neuronal cell classes and types in the vertebrate retina

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-01 | GSE237215 | GEO

Cell type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-02 | GSE198367 | GEO