BATF orchestrates the functional specification and metabolic reprogramming in Treg cells
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ABSTRACT: Purpose: Identification of the differentially expressed genes and metabolic pathways in resting and activated WT and BATF-deficient Treg cells Methods: RNA was purified from resting of stimulated (aCD3-CD38/IL-2 for 48 h)Treg cells isolated from WT or Foxp3CreBatffl/fl mice Results: Loss of BATF promotes triacylglycerol biosynthesis in Treg cells. Conclusions: BATF is crucial to coordinate the suppressive function and triacylglycerol metabolism of Treg cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE149197 | GEO | 2021/03/02
REPOSITORIES: GEO
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