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Expression data from BATF-deficient Treg cells

ABSTRACT: FoxP3 is a central regulator of immunological tolerance, controlling the development and function of regulatory T (Treg) cells. To dissect the complex processes orchestrated by FoxP3, we investigated impacts of three autoimmune disease-associated missense FoxP3 mutations in mice. The I363V and R397W mutations were loss-of-function mutations, causing multi-organ inflammation by globally compromising Treg cell physiology. By contrast, the A384T mutation induced a distinctive tissue-restricted inflammation by specifically impairing the ability of Treg cells to compete with pathogenic T cells in certain non-lymphoid tissues. Because BATF expression was down-regulated in A384T Treg cells, we hypothesized that its down-regulation could account for the A384T Treg cell phenotype and addressed whether BATF-deficient Treg cells are phenotypically similar to A384T Treg cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE89656 | GEO | 2017/08/01

SECONDARY ACCESSION(S): PRJNA352830

REPOSITORIES: GEO

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Batf stabilizes Th17 cell development via limiting STAT5 signaling pathway (ChIP-Seq)

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