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Single cell RNA-seq activated microglia cells after irradiation (IR)

ABSTRACT: Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-inflammatory microglial response, at least in the adult brain. Using single cell and bulk RNA sequencing combined with histology, we show that the microglial response in the juvenile mouse hippocampus is rapid, but returns toward normal within 1 week. We found that a single microglial cell simultaneously upregulates transcripts associated with pro- and anti-inflammatory microglial phenotypes. Our results indicate that microglia are involved in the initial stages, but may not be responsible for driving long-term inflammation in the juvenile brain.

ORGANISM(S): Mus musculus

PROVIDER: GSE149247 | GEO | 2020/06/01

REPOSITORIES: GEO

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