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RNA-seq of control and USP7 siRNA transfected ES and 2-cell like cells

ABSTRACT: 2-cell-like cells (2CLCs) that resemble 2-cell stage embryos can arise with a very low frequency in ES cell cultures. Here, we found a novel factor, Usp7 which promotes 2CLC transition from ESCs and its effect is dependent of DNA replication. Endogenous retroviruses and 2-cell stage specific genes are significantly upregulated in siUSP7-transfected 2CLCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE149341 | GEO | 2022/01/18

REPOSITORIES: GEO

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RNA-seq of control and USP7 siRNA transfected ES and 2-cell like cells

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