Transcriptomics

Dataset Information

0

Single cell RNA-seq reveals high heterogeneity among human γδ T cells.


ABSTRACT: Human γδ T cells take a small but important part in the immune system. Human γδ T cells are usually categorized by the V gene of their T cell receptor (TCR) δ chain; most of which are Vδ1+ or Vδ2+. Naive γδ T cells are often found from neonates and cytotoxic γδ T cells (γδCTLs) are frequent in adults. However, phenotypes and the developmental programs of human γδ T cells are not fully clear. Here, by single-cell RNA sequencing (sc-RNAseq) of transcriptome and T cell receptor (sc-TCRseq) on γδ T cells from neonates and adults, we revealed human γδ T cells can be divided as naïve T cells, γδCTLs, and γδNKT cells which are featured by pro-Vδ1, Vδ1, and Vδ2 TCR repertoire, respectively. γδNKT cells can be further described as γδNKT-1, γδNKT-2, and γδNKT-17 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE149356 | GEO | 2020/07/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-01-31 | GSE223808 | GEO
2023-01-31 | GSE223806 | GEO
2019-01-08 | GSE124731 | GEO
2024-07-03 | GSE271442 | GEO
2024-08-06 | GSE274083 | GEO
2024-08-01 | GSE266504 | GEO
2024-03-04 | GSE260763 | GEO
2024-07-11 | GSE236384 | GEO
2022-08-19 | GSE180059 | GEO
2023-09-25 | GSE232529 | GEO