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Transcriptome profile of fibroblasts in chronic thromboembolic pulmonary hypertension

ABSTRACT: The hallmark of chronic thromboembolic pulmonary hypertension (CTEPH) is fibrotic transformation of pulmonary arterial thrombus, leading to mechanical obstruction of pulmonary arteries. We report the transcriptome profile of fibroblasts isolated from pairs of CTEPH thrombus and pulmonary artery adventitia of the same patient. Fibroblasts isolated from CTEPH thrombus demonstrated upregulation of genes associated with the TGF-β pathway indicating that TGF-β upregulation is associated with the intravascular remodeling process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE149413 | GEO | 2020/12/31

REPOSITORIES: GEO

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Expression patterns in chronic thromboembolic pulmonary hypertension

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Transcriptome profile of fibroblasts in chronic thromboembolic pulmonary hypertension

Project description:Transcriptome profile of fibroblasts in chronic thromboembolic pulmonary hypertension

| PRJNA628645 | ENA

Transcriptome sequencing and ceRNA (lncRNA-miRNA-mRNA) network construction identified the key molecular markers and signaling pathways of chronic thromboembolic pulmonary hypertension

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