Transcriptomics

Dataset Information

0

Brain-infiltrating CD8+ T cell transcriptional activity after acute infection and during CNS autoimmunity [RNA-Seq]


ABSTRACT: Gene expression of WT and Tox -/- P14 CD8+ T cells adoptively transfered in WT and MOG-GP recipient mice following intracranial infection with LCMV-GP. CD8+ T cells play a pivotal role in eliminating pathogens or tumors, but they equally exert tissue damage in autoimmune or chronic inflammatory diseases. While the mechanisms regulating the differentiation of CD8+ T cells in chronic infections and cancer are just beginning to be unraveled, we still lack knowledge about how this unfolds in autoimmune diseases. Here, we investigated in a model of chronic central nervous system autoimmunity, the transcriptional and epigenetic landscape of autoreactive brain infiltrating CD8+ T cells and how these cells diverge from classical long-lived memory CD8+ T emerging after virus infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE149550 | GEO | 2020/12/16

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-12-16 | GSE149642 | GEO
2021-03-30 | GSE159705 | GEO
2024-05-14 | GSE267422 | GEO
2019-08-01 | E-MTAB-7110 | biostudies-arrayexpress
2023-01-25 | GSE189580 | GEO
2009-11-01 | E-MEXP-2237 | biostudies-arrayexpress
2010-12-31 | E-MEXP-2703 | biostudies-arrayexpress
2020-08-21 | E-MTAB-9132 | biostudies-arrayexpress
2017-10-24 | GSE93909 | GEO
2023-03-30 | GSE227049 | GEO