Genome-wide transcriptional analysis of CD8+ brain TRM during CNS autoimmunity
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ABSTRACT: CD8+ TRM are described in autoimmune and chronic inflammatory diseases. However, we still lack knowledge about mechanisms regulating TRM reactivation, in particular in autoimmune diseases. Here, we investigated in a model of TRM-driven central nervous system autoimmunity the transcriptional landscape of self-reactive brain TRM and the requirement of these cells for CD4+ T cell help.
ORGANISM(S): Mus musculus
PROVIDER: GSE189580 | GEO | 2023/01/25
REPOSITORIES: GEO
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