Transcriptomics

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Impact of vancomycin on the ileum and colon of mice-bearing singeneic mammary carcinoma expressing human HER2


ABSTRACT: Starting from the evidences of gut microbiota role in tumor development, progression and response to therapy, this project was aimed at evaluating the effect of antibiotic treatment on intestine. The intestinal flora of FVB mice was altered by the oral administration of vancomicyn, mice were then injected with MI6 cells, a singeneic tumor cells line established from spontanueous mammary tumor developped in transgenic d16HER2-transgenic mice [Castagnoli L, 2014]. To analyze the impact of vancomycin on intestinal mucosa, a gene expression profile was performed on colon and ileum samples.

ORGANISM(S): Mus musculus

PROVIDER: GSE149712 | GEO | 2022/03/28

REPOSITORIES: GEO

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