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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE149804 | GEO | 2020/08/31

REPOSITORIES: GEO

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Basis of specificity for a conserved and promiscuous chromatin remodeling protein.

Project description:Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor. Here, we show that Isw2 instead acts as an obligately targeted nucleosome remodeler in vivo through physical interactions with sequence-specific factors. We demonstrate that Isw2-recruiting factors use small and previously uncharacterized epitopes, which direct Isw2 activity through highly conserved acidic residues in the Isw2 accessory protein Itc1. This interaction orients Isw2 on target nucleosomes, allowing for precise nucleosome positioning at targeted loci. Finally, we show that these critical acidic residues have been lost in the Drosophila lineage, potentially explaining the inconsistently characterized function of Isw2-like proteins. Altogether, these data suggest an 'interacting barrier model,' where Isw2 interacts with a sequence-specific factor to accurately and reproducibly position a single, targeted nucleosome to define the precise border of phased chromatin arrays.

| S-EPMC7968928 | biostudies-literature

Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [RNA-Seq]

Project description:We propose an interacting barrier mechanism for cooperation between Isw2-related proteins and sequence-specific DNA binding factors.

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [Mnase-seq]

Project description:We propose an interacting barrier mechanism for cooperation between Isw2-related proteins and sequence-specific DNA binding factors.

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [ChIP-Seq]

Project description:We propose an interacting barrier mechanism for cooperation between Isw2-related proteins and sequence-specific DNA binding factors.

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein

Project description:Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [ChIP-Seq]

Project description:Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [ChIP-Seq]

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [RNA-Seq]

Project description:Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [RNA-Seq]

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Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [Mnase-seq]

Project description:Basis of Specificity for a Conserved Promiscuous Chromatin Remodeling Protein [Mnase-seq]

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Multiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-12-24 | E-GEOD-53585 | biostudies-arrayexpress

Coordinated Chromatin Remodeling induced by Demethylation requires SRCAP mediated H2A.Z exchange

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