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MiR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP]

ABSTRACT: miR-146a is a known anti-inflammatory miRNA. Intringuigly, it is overexpressed in RAS-induced senescent cells which is accompanied with a rich pro-inflammatoy secretpry phenotype. We aim to study possible sponges for miR-146a.

ORGANISM(S): Homo sapiens

PROVIDER: GSE150324 | GEO | 2021/05/11

REPOSITORIES: GEO

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miR-146a regulates many lncRNAs in RAS induced senescence [Anti-146a]

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miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP

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Project description:We have found expression of miR-146a up-regulated in gastric cancer. To identify new targets of miR-146a we profiled the transcriptome after miR-146a over-expression in the human gastric cancer cell line SNU638. SNU638 cells were transfected in triplicates with 50 nM miR-146a or control (siGlo) using Lipofectamine 2000. Total RNA was harvested 24 h after transfection using Trizol reagent. There are a total of six arrays included in this experiment, including three biological replicates of mRNA expression after miR-146a over-expression and three controls in SNU638 cells.

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