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R1 mESC Exposed to Butyrate

ABSTRACT: To assess the effect of sodium butyrate exposure on mouse ESC grown without self-renewal support (I.e. without feeders or LIF) - these cells were compared to cells grown without sodium buytrate, but with added mouse LIF via Agilent whole mouse genome array

ORGANISM(S): Mus musculus

PROVIDER: GSE15107 | GEO | 2009/03/05

SECONDARY ACCESSION(S): PRJNA123099

REPOSITORIES: GEO

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Transcription profiling of mouse R1 mESC exposed to butyrate

Project description:To assess the effect of sodium butyrate exposure on mouse ESC grown without self-renewal support (I.e. without feeders or LIF) - these cells were compared to cells grown without sodium buytrate, but with added mouse LIF via Agilent whole mouse genome array Experiment Overall Design: R1 mESC were grown under 2 conditions, with mLIF on gelatin or without LIF on gelatin for 15 passages to compare change in the RNA profile

2009-03-15 | E-GEOD-15107 | biostudies-arrayexpress

Transcription profiling of human H1 hESC exposed to butyrate

Project description:To assess the effect of sodium butyrate exposure on human ESC grown without culture support for self-renewal (I.e. without conditioned medium and added bFGF) - three groups were compared - H1 culture in feeder conditioned medium vs without conditioned medium in 0.2 mM sodium butyrate vs. grown in sodium butyrate for 4 passages followed by return to conditioned medium conditions for 3 passages. The three groups were grown in triplicate and compared on Agilent whole human genome array Experiment Overall Design: H1 hESC were grown under 3 conditions: A. 48 passages total, the last 9 passages off of feeders on Matrigel in feeder conditioned medium B. 48 passages total, within the last 9 passges, #39-41 were in conditioned medium and #42-48 were without conditioned medium and added bFGF but with 0.2 mM sodium butyrate on Matrigel C. 49 passages total, within the last 10 passages #39-41 were in conditioned medium, #42-46 in 0.2 mM sodium butyrate (without feeder of bFGF support) and #47-49 back to conditioned medium + bFGF. The RNA from these cells were compared via Agilent whole human genome array.

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H1 hESC Exposed to Butyrate

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BG02 hESC Exposed to Butyrate

Project description:To assess the effect of sodium butyrate exposure on human ESC grown without culture support for self-renewal (I.e. without conditioned medium and added bFGF) in support of data generated on H1 hESC - two groups were compared - BG02 culture in feeder conditioned versus on sodium butyrate - in triplicate and compared on Agilent whole human genome array

2009-03-05 | GSE15109 | GEO

BG02 hESC Exposed to Butyrate

Project description:To assess the effect of sodium butyrate exposure on human ESC grown without culture support for self-renewal (I.e. without conditioned medium and added bFGF) in support of data generated on H1 hESC - two groups were compared - BG02 culture in feeder conditioned versus on sodium butyrate - in triplicate and compared on Agilent whole human genome array BG02 hESC were grown under two conitions - A. for 31 passages on Matrigel in feeder conditioned medium and B. for 29 passages on Matrigel in feeder conditioned medium followed by 20 passages in 0.2 mM sodium butyrate without conditioned medium and in human ES cell medium containing no added bFGF

2009-03-04 | E-GEOD-15109 | biostudies-arrayexpress

Effect of sodium butyrate on colorectal cancer cell line HT-29

Project description:Analysis of colorectal cancer (CRC) cell line HT-29 treated with Sodium Butyrate. Sodium Butyrate, a HDAC inhibitor present in gut, can differentiate the undifferentiated HT-29 to enterocytes by the induction of brush border enzyme alkaline phosphatase. Results provide the transcriptional profiling underlying the butyrate-induced differentiation of CRC.

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BUTYRATE ENEMAS ON PATIENTS WITH ENTEROSTOMY

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