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Transcriptome profiling of SUM159 and derivatives with different metastasis capability

ABSTRACT: Triple negative breast cancer cell line SUM159 labeled with triple reporter (TR, TK-GFP-fLUC) injected into Nude mice via mammary fat pad and tail vein injection. Tumor progression is monitored by in vivo bioluminescent imaging. Tumors from mammary and lung were isolated and cultured. These derivatives cells are further tested for their capability to develop mammary primary tumor and metastasis in lung and bone in mice. The total RNA samples are extracted from the panel of SUM159 and derivatives and the transcriptome profiles are determined by microarray. The correlation of transcriptome of the cells to metastasis capability indicated candidate genes and regulatory pathways of metastasis of TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151198 | GEO | 2021/01/13

REPOSITORIES: GEO

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Transcriptome profiling of SUM159 and derivatives with different metastasis capability

Project description:Transcriptome profiling of SUM159 and derivatives with different metastasis capability

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Expression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures

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