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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Danio rerio

PROVIDER: GSE151679 | GEO | 2021/09/15

REPOSITORIES: GEO

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

Project description:We report the gene expression differences between the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV

2021-09-15 | GSE151678 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

Project description:We report the gene expression differences between the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV

2021-09-15 | GSE151677 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

Project description:We report how the ZMEL1-PRO cell line changes following CRISPR-Cas9 inactivation of tfap2a and tfap2e

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Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

Project description:We report single-cell gene expression profiling of the zebrafish melanoma cell lines ZMEL1-PRO and ZMEL1-INV under multiple in vitro and in vivo (zebrafish transplant) conditions

2021-09-15 | GSE152998 | GEO

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

| PRJNA636815 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [tfap2a/e]

| PRJNA636816 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [2D culture]

| PRJNA636817 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [3D culture]

| PRJNA636818 | ENA

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

Project description:Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma [RNA-Seq]

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Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis.

Project description:The relationships of pregnancy and melanoma have been debatable. Our aim was to assess the influence of gestation on the course of melanoma in a classic murine model of tumor progression and in women. B16 mouse melanoma cells were injected in nonpregnant or pregnant mice on day 5 of gestation. Animals were evaluated for tumor progression, metastases, and survival. Tumor sections were analyzed for lymphatic and blood vessel number and relative surface and expression of angiogenic growth factors. Finally, primary melanomas from pregnant and nonpregnant women, matched for age and tumor thickness, were also considered. Tumor growth, metastasis, and mortality were increased in B16-injected pregnant mice. Tumors displayed an increase in intratumoral lymphangiogenesis during gestation. This increased lymphatic angiogenesis was not observed in normal skin during gestation, showing its specificity to the tumor. An analysis of melanoma from pregnant and matched nonpregnant women showed a similar increase in lymphatic vessels. Tumors from pregnant mice had increased expression of vascular endothelial growth factor A at the RNA and protein levels. The increased vascular endothelial growth factor A production by melanoma cells could be reproduced in culture using pregnant mouse serum. In conclusion, pregnancy results in increased lymphangiogenesis and subsequent metastasis. Caution should be applied in the management of patients with advanced-stage melanoma during gestation.

| S-EPMC3078435 | biostudies-literature

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