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Single-cell transcriptome analysis of endothelial cell heterogeneity under laminar shear stress

ABSTRACT: Heterogeneity of endothelial cells that form the innermost layer of all vessels is critical for vascular sprouting and angiogenesis. After new vessels form, endothelial cell heterogeneity is believed to be gradually lost as vessels respond to flow-mediated signals, mature, remodel and become homeostatic. However, whether and at what level endothelial cell lost heterogeneity is poorly understood. Here we investigated heterogeneity change of endothelial cells under homeostatic laminar shear tress in comparison to static cultures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151867 | GEO | 2021/05/25

REPOSITORIES: GEO

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