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Direct and indirect podocyte injury manifested in a partial podocytectomy mouse model

ABSTRACT: Injured podocytes indirectly influence neighboring podocytes. To study the indirect effect, we generated mosaic mice, Pod-hCD25T/G, in which podocytes express either hCD25 + tdTomato or EGFP alone. A hCD25-targetting immunotoxin LMB2 was injected into the mosaic mice to induce injury selectively in tdTomato(+) podocytes. We analyzed RNA expressing profile in tdTomato(+) (hCD25 expressing) and EGFP(+) (hCD25 not expressing) podocytes before and after LMB2 injection.

ORGANISM(S): Mus musculus

PROVIDER: GSE151869 | GEO | 2021/03/08

REPOSITORIES: GEO

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