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Genome-wide transcriptional regulation of the long non-coding RNA steroid receptor RNA activator in human erythroblasts

ABSTRACT: We report a novel function of the lncRNA SRA in regulation of global gene expression through direct chromatin binding in human erythroleukemia cell line K562 and in primary human proerythroblasts derived from HSCs. We demonstrate that SRA, together with CTCF, H3K4me3, and H3K27me3, occupies various genomic regions. Further, SRA facilitates transcriptome-wide expression of erythroid program and expression of erythroid markers in K562 and in primary human proerythroblasts. Hence, a possible function of the lncRNA SRA during erythroid development is to promote transcription of erythroid genes and therefore erythropoiesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE151926 | GEO | 2020/07/04

REPOSITORIES: GEO

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Genome-wide map of long non-coding RNA steroid receptor RNA activator (SRA) in human erythroleukemic K562 cell line

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