Transcriptomics

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Improved maturity and yield of pluripotent stem cell-derived hepatocytes for 2D and 3D modeling of human liver pathophysiology


ABSTRACT: Robust and scalable differentiation of human pluripotent stem cells into high-quality hepatocyte-like cells (HLC) is achieved by acting on Wnt/b-catenin and TGFb pathways and taking advantage of latest knowledge on human liver development. Obtained HLC are comparable to primary human hepatocytes and superior to stem cell-derived hepatocytes generated with previously described protocols. As a proof of concept, such HLC were used to assess drug hepatotoxicity and study human ductal plate and bile duct morphogenesis in a complex liver organoid model.

ORGANISM(S): Homo sapiens

PROVIDER: GSE152390 | GEO | 2022/02/03

REPOSITORIES: GEO

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