De novo generation of macrophage from placenta-derived hemogenic endothelium
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ABSTRACT: We profile the transcriptional landscape of mouse fetal placenta and identify four distinct types of haematopoietic stem/progenitor cells (HSPCs) during mid-gestation using single-cell RNA sequencing. We experimentally validate and uncover that a subpopulation of placental endothelial cells exhibits hemogenic endothelial (HE) potential and shares transcriptional features with HE cells in the aorta-gonad-mesonephros (AGM) region.
ORGANISM(S): Mus musculus
PROVIDER: GSE152903 | GEO | 2021/06/30
REPOSITORIES: GEO
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