Discovery of novel hypermethylated gene loci in prostate cancer using genome wide coverage CpG island microarrays
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ABSTRACT: In order to identify methylation changes in prostate cancer, we performed a genome-wide analysis of DNA methylation using Agilent human CpG island arrays. We then chose specific genes to validate methylation both in the same cases as were hybridized to the array (using quantitative EpiTYPER analysis) and in an independent series of prostate cancer samples (using MethyLight quantitative methylation specific PCR). We specifically chose low grade (Gleason score 6 cases) and high grade (Gleason score 8 cases) to discover methylated genes/loci that may be involved in the progression to a higher grade of prostate cancer.
ORGANISM(S): Homo sapiens
PROVIDER: GSE15298 | GEO | 2009/03/27
SECONDARY ACCESSION(S): PRJNA116593
REPOSITORIES: GEO
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