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The response of A549 transcriptome to RNA Pol II slowdown with alpha-amanitin and DRB

ABSTRACT: According to current estimates, more than 40% of nascent introns are spliced co-transcriptionally and, consequently, the speed of RNA polymerase II elongation must fundamentally affect the rate of RNA folding, spliceosome assembly, and the resulting mature transcript. RNA-Seq data was generated using RNAPII elongation inhibitors DRB and a-amanitin in A549 cells and used to look at genome-wide splicing changes

ORGANISM(S): Homo sapiens

PROVIDER: GSE153303 | GEO | 2020/06/27

REPOSITORIES: GEO

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