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PTBP1 is necessary for dendritic cells to regulate T cells homeostasis and antitumor immunity

ABSTRACT: Dendritic cells (DCs) play an important role in innate and adaptive immunity. DCs could sense environment pathogens and tumors, presenting those antigens to T cells. PTBP1, an RNA-binding protein, the function in DCs is unknown. Here, we found PTBP1 specific deficiency in DCs could impair T cell homeostasis. PTBP1 deletion in DCs could enhance antitumor immunity and increase asthma exacerbation. Further studies demonstrate that PTBP1 negatively regulates the induction of a subset of IFN-response genes. These findings revealed the novel functions of PTBP1 in DCs and might be a potential therapeutic target for tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE153401 | GEO | 2021/01/10

REPOSITORIES: GEO

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PTBP1 is necessary for dendritic cells to regulate T cells homeostasis and antitumor immunity

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