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Glioma cells response Interleukin-33 (IL-33) [microarray]

ABSTRACT: Determination of the molecular mechanism of IL33 on glioma cells Since IL-33 is known to associate with chromatin and regulate transcriptional activity and that nuclear expression of IL-33 increases glioma progression, we determined Nuclear IL-33 regulates the expression and secretion of inflammatory cytokines in glioma cells. Using these parameters 340 genes were induced by the ectopic expression of IL-33 and an additional 377 genes were downregulated. Gene ontology terms over-represented in the genes induced by IL-33 include three major clusters that associate with cytokine activity and inflammation

ORGANISM(S): Homo sapiens

PROVIDER: GSE153486 | GEO | 2020/08/21

REPOSITORIES: GEO

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Single cell profiling of cerebral immune cells in the Interleukin-33 (IL-33) driven tumor microenvironment

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