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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of neonatal rat ventricular cardiac myocytes treated with interleukin 33 for 0.5, 1 or 2 hours

ABSTRACT: Study of the effect of interleukin 33 (IL33) on transcript expression in neonatal rat ventricular cardiac myocytes at 0.5, 1 or 2 h

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Clerk

PROVIDER: E-MEXP-1912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.

Barrett Oliver P T OP Yndestad Arne A Marshall Andrew K AK Sugden Peter H PH Clerk Angela A

Cytokine 20121207 2

In the heart, inflammatory cytokines including interleukin (IL) 1β are implicated in regulating adaptive and maladaptive changes, whereas IL33 negatively regulates cardiomyocyte hypertrophy and promotes cardioprotection. These agonists signal through a common co-receptor but, in cardiomyocytes, IL1β more potently activates mitogen-activated protein kinases and NFκB, pathways that regulate gene expression. We compared the effects of external application of IL1β and IL33 on the cardiomyocyte trans ...[more]

PMID: 23219998

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