Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CRTC3 is a coincidence detector for cAMP and growth factor signals in melanocytes and melanoma.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE154117 | GEO | 2022/04/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

CRTC3 is a coincidence detector for cAMP and growth factor signals in melanocytes and melanoma.

Project description:CRTC3 is a coincidence detector for cAMP and growth factor signals in melanocytes and melanoma.

| PRJNA645147 | ENA

Primary uveal melanoma cells, normal uveal melanocytes, neural crest stem cells, embryonic stem cells and uveal melanoma cell lines

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-02-14 | E-GEOD-44299 | biostudies-arrayexpress

Melan-a melanocytes and B16 melanoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2008-07-31 | GSE11588 | GEO

Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-04-29 | E-GEOD-54059 | biostudies-arrayexpress

HBI1 integrates hormonal and environmental signals to regulate the trade-off between growth and immunity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-05-30 | E-GEOD-53100 | biostudies-arrayexpress

TNFα-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes.

Project description:Analyses of expression and regulation of ganglioside synthases in melanocytes are important to understand roles of gangliosides in melanomagenesis. In this study, we analyzed the expression and regulatory mechanisms of glycosyltransferase genes responsible for ganglioside synthesis in normal melanocytes. We reported previously that culture supernatants of UVB-irradiated keratinocytes induced upregulation of ganglioside GD3 synthase gene in melanocytes, and mainly TNFα was responsible for it. Then, we found that elimination of dibutyryl cyclic AMP and IBMX from the medium also resulted in upregulation of the GD3 synthase gene. The addition of α-melanocyte-stimulating hormone which increases cAMP, to the medium led to a significant reduction in the GD3 synthase gene expression level, and a PKA inhibitor enhanced the GD3 synthase gene level. These results suggest that signals mediated via TNFα and cAMP oppositely regulate GD3 synthase gene expression in melanocytes. The results of an IKK inhibitor indicate the possibility that TNFα induces GD3 synthase gene expression via NF-κB signaling in melanocytes. When melanoma cells were treated by these factors, no fluctuation in the GD3 synthase gene expression level was observed, although an IKK inhibitor significantly suppressed it, suggesting that ganglioside synthase genes are regulated in distinct manners between melanocytes and melanomas.

| S-EPMC6791844 | biostudies-other

Transcriptional Profile and Chromatin Accessibility in Zebrafish Melanocytes and Melanoma Tumors

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-24 | GSE178803 | GEO

Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate iPSC reprogramming of lineage-committed myeloid progenitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-08-09 | GSE35029 | GEO

A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-11 | GSE154877 | GEO

INO80 governs super-enhancer-mediated oncogenic transcription and tumor growth in melanoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series