Transcriptomics

Dataset Information

0

Global Gene Expression in the Human Fetal Testis and Ovary


ABSTRACT: This study describes a temporal profile of gene expression from normal human fetal testes and ovaries. Gonads from 34 fetuses between 9 weeks and 20 weeks of gestation were obtained from the Department of Pathology and the Birth Defects Research Laboratory at the University of Washington. Relative transcript levels were determined using the Affymetrix Human Genome U133A Plus 2.0 arrays. Sex determination occurs in the human gonad at approximately 6 weeks gestation with development of the testis driven by expression of SRY. In this study, SRY transcript was present and elevated at 9 weeks gestation in the testis but absent in the ovary. The transcript levels of other testis-specific factors SOX9, AMH, and the steroidogenic genes CYP17a1, CYP11a1, STAR and HSD17β3 were all significantly higher in the testis. In contrast, transcripts known to be involved in meiosis including STRA8, SPO11, SYCP3, TEX11, TEX14 and STAG3 showed highest expression in the fetal ovary beginning at week 12. These gene expression profiles will be a resource for understanding and defining normal gonad development and provide the opportunity to dissect abnormal development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE15431 | GEO | 2009/05/01

SECONDARY ACCESSION(S): PRJNA115785

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2009-05-11 | E-GEOD-15431 | biostudies-arrayexpress
2022-02-17 | PXD026927 | Pride
2017-03-27 | E-MTAB-5525 | biostudies-arrayexpress
2020-02-13 | GSE116278 | GEO
2014-07-31 | E-GEOD-58612 | biostudies-arrayexpress
2014-07-31 | GSE58612 | GEO
2010-12-20 | GSE23908 | GEO
2013-12-27 | E-MEXP-3879 | biostudies-arrayexpress
2024-04-24 | PXD051687 |
2017-01-10 | GSE81524 | GEO