Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of Tmem184b dependent gene expression changes during sensory neuron differentiation in vitro

ABSTRACT: Our objective was to evaluate the gene expression changes occuring in early sensory neuron development that were lost in the absence of Tmem184b and restored upon its reintroduction into mutant neurons in culture.

ORGANISM(S): Mus musculus

PROVIDER: GSE154435 | GEO | 2020/07/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Evaluation of Tmem184b dependent gene expression changes during sensory neuron differentiation in vitro

Project description:Evaluation of Tmem184b dependent gene expression changes during sensory neuron differentiation in vitro

| PRJNA646254 | ENA

Evaluating developmental effects of Tmem184b in dorsal root ganglia

Project description:We evaluated transcriptomic signatures at critical timepoints of sensory differentiation in wild type and Tmem184b mutant mice.

2020-07-14 | GSE154354 | GEO

Comparison of wild type and Tmem184b mutant adult DRG

Project description:The goal of this study was to evaluate gene expression that is dependent upon Tmem184b expression. Our objective was to identify pathways controlled by Tmem184b that may influence development or behavior of neurons.

2020-07-14 | GSE154316 | GEO

Investigating effect of TMEM184B mutation on hippocampal gene expression in 5 month and 15 month old mice

Project description:The objective of this study was to determine whether TMEM184B influenced the expression of genes important for neuronal function or memory.

2022-05-25 | GSE204831 | GEO

Comparison of olfactory sensory neuron subtypes

Project description:Olfactory sensory neurons (OSNs) express a single abundant olfactory receptor (OR). To assess the differences in gene expression between different OSN sub-types we collected three pools of neurons that express one OR and compared them to three pools of neurons that express another. After extracting RNA from these pools, the samples were multiplexed and sequenced using the Illumina Hiseq2500 platform.This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

2016-02-09 | E-ERAD-436 | biostudies-arrayexpress

Peripheral Sensory Neuron EC-tagging experiments

Project description:Peripheral Sensory Neuron EC-tagging experiments

| PRJNA663560 | ENA

Single-cell RNAseq Reveals Seven Classes of Visceral Sensory Neuron

Project description:Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. The principal neural unit in the bowel encoding these stimuli is the visceral sensory neuron with endings at the mucosa, intramurally and along mesenteric blood vessels. Sensory neurons activate reflex pathways and give rise to conscious sensation, however, the diversity and division of function within these neurons is poorly understood. The identification of signalling pathways contributing to visceral sensation is constrained by the current paucity of molecular markers. Here we overcome these limitations by comprehensive transcriptomic profiling and unsupervised clustering of single colonic sensory neurons revealing 7 classes characterised from both lumbar splanchnic (LSN) and pelvic nerves (PN). We identify and classify neurons based on novel marker genes, confirm translation of patterning to protein expression and show subtype-selective differential agonist activation, describing sensory diversity encompassing all modalities of colonic neuronal sensitivity.

2018-02-27 | GSE102962 | GEO

Expression data from mouse proprioceptive sensory neuron subclasses.

Project description:Proprioception relies on two main classes of proprioceptive sensory neurons (pSNs). These neurons innervate two distinct peripheral receptors in muscle, muscle spindles (MSs) or Golgi tendon organs (GTOs), and synapse onto different sets of spinal targets, but the molecular basis of their distinct pSN subtype identity remains unknown. We used microarray analysis to compare gene expression profiles between MS- and GTO- innervating proprioceptors. We generated transgenic mice in which MS and GTO pSNs are labelled with different fluorescent proteins (see de Nooij et al., 2015 for details). We used Fluorescent Activated Cell Sorting (FACS) to isolate the MS and GTO pSN subsets from dissociated DRG from p7-10 transgenic mice. Neurons from multiple FACS experiments were pooled into three samples each for the MS and GTO pSN subset.

2015-01-14 | E-GEOD-64941 | biostudies-arrayexpress

Runx1 Controls Auditory Sensory Neuron Diversity (iCKO)

Project description:Runx1 Controls Auditory Sensory Neuron Diversity (iCKO)

| PRJNA864782 | ENA

Runx1 Controls Auditory Sensory Neuron Diversity (CKO)

Project description:Runx1 Controls Auditory Sensory Neuron Diversity (CKO)

| PRJNA864783 | ENA