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Investigating effect of TMEM184B mutation on hippocampal gene expression in 5 month and 15 month old mice

ABSTRACT: The objective of this study was to determine whether TMEM184B influenced the expression of genes important for neuronal function or memory.

ORGANISM(S): Mus musculus

PROVIDER: GSE204831 | GEO | 2022/05/25

REPOSITORIES: GEO

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Investigating effect of TMEM184B mutation on hippocampal gene expression in 5 month and 15 month old mice

Project description:Investigating effect of TMEM184B mutation on hippocampal gene expression in 5 month and 15 month old mice

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Comparison of wild type and Tmem184b mutant adult DRG

Project description:The goal of this study was to evaluate gene expression that is dependent upon Tmem184b expression. Our objective was to identify pathways controlled by Tmem184b that may influence development or behavior of neurons.

2020-07-14 | GSE154316 | GEO

Evaluation of Tmem184b dependent gene expression changes during sensory neuron differentiation in vitro

Project description:Our objective was to evaluate the gene expression changes occuring in early sensory neuron development that were lost in the absence of Tmem184b and restored upon its reintroduction into mutant neurons in culture.

2020-07-15 | GSE154435 | GEO

Evaluating developmental effects of Tmem184b in dorsal root ganglia

Project description:We evaluated transcriptomic signatures at critical timepoints of sensory differentiation in wild type and Tmem184b mutant mice.

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Do 15-month-old infants understand false beliefs?

Project description:For more than two decades, researchers have argued that young children do not understand mental states such as beliefs. Part of the evidence for this claim comes from preschoolers' failure at verbal tasks that require the understanding that others may hold false beliefs. Here, we used a novel nonverbal task to examine 15-month-old infants' ability to predict an actor's behavior on the basis of her true or false belief about a toy's hiding place. Results were positive, supporting the view that, from a young age, children appeal to mental states--goals, perceptions, and beliefs--to explain the behavior of others.

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Nfat5 is involved in the hyperosmotic regulation of Tmem184b, which could be involved in ibuprofen transport in renal MDCK I cells

Project description:Purpose: To investigate the involvement of Nfat5 in the regulation of an ibuprofen transporter Method: Reverse transfection with siRNA against Nfat5 was used to knockdown Nfat5 in MDCK I cells. The uptake of both radiolabelled taurine and ibuprofen was measured in MDCK I cells, first treated with siRNA against Nfat5 for 24 h and afterwards cultivated with raffinose-supplemented normal growth medium (500 mOsm) for 24 h. The knock down of NFat5 was investigated by qpCR and western blotting. A transcriptome analysis of MDCK I cells treated with siRNA against Nfat5 was performed. Validation of the transcriptome analysis was perform with qPCR and radiolabelled uptake of ibuprofen. Results: The siRNA transfection resulted in a knock down of Nfat5, and the uptake of both taurine and ibuprofen was significant decreased in the transfected MDCK I cells. The transcriptome analysis of MDCK I cells treated with siRNA against Nfat5 revealed genes regulated by Nfat5 during hyperosmotic exposure. qPCR and the transciptome analysis showed an involvement of Nfat5 in the hyperosmotic regulation of Tmem184 and uptake in Tmem184b-siRNA treated MDCK I cells showed that Tmem184b might be involved in uptake of ibuprofen. Conclusion: The regulation of Tmem184b was found regulated by Nfat5 and could be a potential possible candidate for the gene product responsible for the uptake of ibuprofen in MDCK I cells

2019-05-10 | GSE122074 | GEO

Comparison of wild type and Tmem184b mutant adult DRG

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Evaluating developmental effects of Tmem184b in dorsal root ganglia

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Do 15-month-old infants prefer helpers? A replication of Hamlin et al. (2007).

Project description:Hamlin et al. found in 2007 that preverbal infants displayed a preference for helpers over hinderers. The robustness of this finding and the conditions under which infant sociomoral evaluation can be elicited has since been debated. Here, we conducted a replication of the original study, in which we tested 14- to 16-month-olds using a familiarization procedure with three-dimensional animated video stimuli. Unlike previous replication attempts, ours uniquely benefited from detailed procedural advice by Hamlin. In contrast with the original results, only 16 out of 32 infants (50%) in our study reached for the helper; thus, we were not able to replicate the findings. A possible reason for this failure is that infants' preference for prosocial agents may not be reliably elicited with the procedure and stimuli adopted. Alternatively, the effect size of infants' preference may be smaller than originally estimated. The study addresses ongoing methodological debates on the replicability of influential findings in infant cognition.

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Gene expression in hippocampal sub-fields of 6.1 month old rTg4510 mice

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