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Aire suppresses CTLA-4 expression from thymic stroma to control autoimmunity

ABSTRACT: We show that thymic epithelial cells in the medulla (mTECs) that present self-antigens (self-Ags) to developing thymocytes for establishing immunological self-tolerance also express CTLA-4 if Aire, loss of which is responsible for the hereditary autoimmunity, is nonfunctional. Upon binding with its ligand, CD80 and CD86, expressed on thymic DCs, CTLA-4/ligand complex was internalized by Aire-deficient mTECs. This attenuated the ability of DCs to provide costimulatory signals and to present self-Ags, resulting in the reduced production of Tregs.

ORGANISM(S): Mus musculus

PROVIDER: GSE155082 | GEO | 2022/03/21

REPOSITORIES: GEO

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