In-depth profiling of transcriptional activity of Aire in mouse mTECs
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ABSTRACT: Aire, a transcriptional regulator whose defect results in the development of autoimmunity, controls the transcriptome in medullary thymic epithelial cells (mTECs) including the genes for self-antigens. Here, we utilized a technique for profiling transcriptome from a single cell (RamDA-seq) to investigate bulk populations in mTECs deeply.
ORGANISM(S): Mus musculus
PROVIDER: GSE222285 | GEO | 2023/01/07
REPOSITORIES: GEO
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