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Gata3 controls stem/progenitor maintenance potential in prostate organoids

ABSTRACT: The adult stem/progenitor cell maintenance in the prostate is regulated by a balance between BMP5 self-renewal signal and GATA3 dampening activity. Here we report that the transcription factor GATA3 controls basal stem/progenitor cell maintenance in the prostate by directly controling the expression of BMP5, a key effector of this activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE155289 | GEO | 2020/08/31

REPOSITORIES: GEO

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Gata3 controls stem/progenitor maintenance potential in prostate organoids

Project description:Gata3 controls stem/progenitor maintenance potential in prostate organoids

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Group 3 innate lymphoid cells continuously require the transcription factor GATA3 after commitment

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Expression of Cdx2 or Gata3 in R1 mouse embryonic stem cells

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