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IER5 is required for Notch-mediated induction of squamous cell differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156488 | GEO | 2020/08/31

REPOSITORIES: GEO

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IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation.

Project description:Notch signaling regulates squamous cell proliferation and differentiation and is frequently disrupted in squamous cell carcinomas, in which Notch is tumor suppressive. Here, we show that conditional activation of Notch in squamous cells activates a context-specific gene expression program through lineage-specific regulatory elements. Among direct Notch target genes are multiple DNA damage response genes, including IER5, which we show is required for Notch-induced differentiation of squamous carcinoma cells and TERT-immortalized keratinocytes. IER5 is epistatic to PPP2R2A, a gene that encodes the PP2A B55α subunit, which we show interacts with IER5 in cells and in purified systems. Thus, Notch and DNA-damage response pathways converge in squamous cells on common genes that promote differentiation, which may serve to eliminate damaged cells from the proliferative pool. We further propose that crosstalk involving Notch and PP2A enables tuning and integration of Notch signaling with other pathways that regulate squamous differentiation.

| S-EPMC7529455 | biostudies-literature

IER5 is required for Notch-mediated induction of squamous cell differentiation [RNA-seq]

Project description:Conditional activation of Notch in squamous cells activates a context-specific gene expression program through lineage-specific regulatory elements. IER5 is a direct Notch-regulated gene and required for Notch-induced differentiation of squamous carcinoma cells.

2020-08-31 | GSE156487 | GEO

IER5 is required for Notch-mediated induction of squamous cell differentiation [H3K27ac ChIP-seq]

2020-08-31 | GSE156485 | GEO

IER5 is required for Notch-mediated induction of squamous cell differentiation [ChIP-seq RBPJ & MAML1]

2020-08-31 | GSE156486 | GEO

IER5 is required for Notch-mediated induction of squamous cell differentiation

Project description:IER5 is required for Notch-mediated induction of squamous cell differentiation

| PRJNA658108 | ENA

IER5 is required for Notch-mediated induction of squamous cell differentiation [RNA-seq]

Project description:IER5 is required for Notch-mediated induction of squamous cell differentiation [RNA-seq]

| PRJNA658112 | ENA

IER5 is required for Notch-mediated induction of squamous cell differentiation [H3K27ac ChIP-seq]