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Immune activation in the brains of fetal and adolescent mice

ABSTRACT: In order to investigate how the immune genes might be involved in the molecular mechanism underlying schizophrenia, we induced immune activation twice in mice, first time during mid-late fetal development stage by intraperitoneal injection (IPI) of lipopolysaccharide (LPS) in to the pregnant mice at G16 (16th day after gestation) and second time during puberty by IPI of LPS into the male offspring at P30 (30th day after birth), and carried out poly-A selected RNA-seq sequencing on the brain at P32 to evaluate transcriptional changes. We used saline as control for LPS, and set the experiments in three combination of saline and LPS treatments: (1) S-S (control group): saline at G16 + saline at P30; (2) L-S: LPS at G16 + saline at P30; (3) S-L: saline at G16 + LPS at P30; (4) L-L: LPS at G16 + LPS at P30.

ORGANISM(S): Mus musculus

PROVIDER: GSE156568 | GEO | 2021/11/10

REPOSITORIES: GEO

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