Characterization of human non-hematopoietic bone marrow cells in non-fibrotic and fibrotic conditions
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ABSTRACT: We isolated non-hematopoietic cells from fibrotic and non-fibrotic human bone marrow and perfomed scRNAseq on them. We identified 3 different stromal populations and 2 populations of hematopoietic progenitors. Our analysis revealed mesenchymal stromal cells (MSC) as pro-fibrotic cells. MSCs were functionally reprogrammed with loss of their progenitor status and acquisition of a pro-fibrotic phenotype in the fibrotic bone marrow. Additionally, stromal cells exhibited an upregulation of pro-inflammatory mediators like S100A8/A9.
ORGANISM(S): Homo sapiens
PROVIDER: GSE156640 | GEO | 2020/11/03
REPOSITORIES: GEO
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