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Characterization of murine non-hematopoietic Gli1+ bone marrow cells in homeostasis

ABSTRACT: We performed fate tracing of Gli1+ cells in homeostasis. Sorted cells were subjected to scRNAseq and integrated with non-hematopoietic cells from mice with myelofibrosis induced by either ThPO- or JAK2V617F-overexpression. Gli1+tdTom+ cells largely overlap with pro-fibrotic adipogenic and osteogenic MSCs, which show a strong upregulation of ECM related transcripts. Additionally, a subgroup of Gli1+tdTom+ cells shows similarity with bone marrow SCPs.

ORGANISM(S): Mus musculus

PROVIDER: GSE156440 | GEO | 2020/11/03

REPOSITORIES: GEO

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