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Brain RNA-seq in the LXS RI strains: Saline and ethanol treatment

ABSTRACT: Purpose: To investigate the effect that acute ethanol tretament (5 g/kg) has on the brain transcriptome and relate that to ethanol-related behaviors. Methods: Male LXS recombinant inbred mice (40 strains; n=2 or 3 per strain) were treated with saline or ethanol (i.p.; 5 g/kg). Paired-end RNA-seq methods were employed to assess mRNA expression in whole brain 8 hours after the treatment. Results: The expression of thousands of transcripts was altered by the ethanol treatment. Thousands of expression QTLs (eQTLs) were mapped. A large percentage of the eQTLs were unique to the treatment.

ORGANISM(S): Mus musculus

PROVIDER: GSE157215 | GEO | 2020/10/28

REPOSITORIES: GEO

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