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Identification of alternative splicing changes upon ablation of cytoplasmic SRSF1.

ABSTRACT: SRSF1, shuttles between the nucleus and cytoplasm affecting post-splicing processes. However, the physiological significance of this remains unclear. Here, we used genome editing to knock-in a nuclear retention signal (NRS) in Srsf1 to create a mouse model harboring a non-shuttling SRSF1 protein. We then assessed whether alblation of shuttling activities of SRSF1 affects its nuclear functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE157269 | GEO | 2021/08/05

REPOSITORIES: GEO

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