Identification of polysomal-association changes upon ablation of cytoplasmic SRSF1
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ABSTRACT: SRSF1, shuttles between the nucleus and cytoplasm affecting post-splicing processes. However, the physiological significance of this remains unclear. Here, we used genome editing to knock-in a nuclear retention signal (NRS) in Srsf1 to create a mouse model harboring a non-shuttling SRSF1 protein. We then assessed how alblation of shuttling activities of SRSF1 affects mRNA translation.
ORGANISM(S): Mus musculus
PROVIDER: GSE161828 | GEO | 2021/08/05
REPOSITORIES: GEO
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