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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

ABSTRACT: Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.

ORGANISM(S): Homo sapiens

PROVIDER: GSE157547 | GEO | 2020/11/18

REPOSITORIES: GEO

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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

Project description:Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.

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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

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Engaging Black Men in Colorectal Cancer Screening

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Analysis of circulating microRNAs during early gestation in Japanese-Black cattle

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