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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

ABSTRACT: Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

PROVIDER: PRJNA644900 | ENA |

REPOSITORIES: ENA

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Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

Project description:Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.

2020-11-18 | GSE153352 | GEO

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

2020-11-18 | GSE157547 | GEO

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

| PRJNA661756 | ENA

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

Project description:Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

| PRJNA661755 | ENA

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-11-18 | GSE157548 | GEO

Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.

Project description:Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

| S-EPMC7876147 | biostudies-literature

Cooperation Between PRMT1 and PRMT6 Drives Lung Cancer Health Disparities Among Black/African American Men

Project description:SUMMARY Non-Hispanic Black/African American (Black/AA) men in the United States have disproportionally higher incidence and mortality rates of lung cancer compared to non-Hispanic White (NHW) men. Biological factors are believed to play critical roles in driving the disparities. Nevertheless, large-scale genomic studies fail to identify significant somatic differences in lung cancer driver genes contributing to the disparities. Elevated expression of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis is observed in many cancer types. Here, we observed a higher PRMT6 expression in lung cancer of Black/AA men compared to NHW men. PRMT6 formed a heteromer complex with PRMT1 to catalyze arginine methylation of interleukin enhancer-binding factor 2 essential for cell proliferation. Disrupting PRMT1/PRMT6 heteromer complex by a competitive peptide reduced cell proliferation in non-small cell lung cancer cell lines and lung cancer patient-derived organoids. This work implicates that PRMT1/PRMT6 heteromer complex contributes to poorer lung cancer outcomes in Black/AA men vs. NHW men that could serve as a target to eliminate cancer health disparities.

2023-12-15 | MSV000093674 | MassIVE

Engaging Black Men in Colorectal Cancer Screening

Project description:To determine the unmet needs, attitudes, barriers and facilitators of African American (AA)/ Black men use of colorectal cancer screening and describe how community leaders such as barbers may act as Community Champions to educate and facilitate screening participation.

| 70579 | ecrin-mdr-crc

Genomic profile of fatigued men receiving localized radiation therapy

Project description:Microarray gene expression of peripheral blood of the prostate cancer patients receiving localized external beam radiation therapy (EBRT) Assay processed at EBRT time points, baseline, midpoint (days 19-21) and endpoint (days 38-42)

2015-06-17 | GSE69961 | GEO

The Methylome-Genome Interactions in Localized Prostate Cancer Define Disease Aggression

Project description:Localized prostate cancer exhibits profound genomic, pathologic, and clinical heterogeneity, and current clinical prognostic factors do not accurately distinguish aggressive from indolent disease for an individual man. We and others have demonstrated that aberrant DNA methylation may be an important driver of aggressive disease. Herein, we analyze the tumor methylomes of 619 localized prostate cancers and assess the interactions between methylation and somatic tumor genomic profiles. We identify three distinct methylation subtypes, including a hypermethylation subtype which is associated with early biochemical recurrence. DNA methylation and gene copy number status synergistically regulate mRNA abundance, and aberrant methylation is strongly associated with common prostate cancer driver aberrations, including mutation density, and with altered RNA abundance profiles. Finally, we identify a set of multivariate methylation biomarkers that are prognostic of rapid biochemical recurrence. Taken together, our data provide the first comprehensive assessment of the interplay between somatic molecular phenotypes and aberrant DNA methylation in localized, non-indolent prostate cancer, and suggest that integrated genome-epigenome analyses may accurately identify men at risk for adverse clinical outcomes in this patient cohort.

2019-06-30 | GSE107298 | GEO

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