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Cranial manipulation modulates cholinergic pathway gene expression in an animal model of age-related cognitive decline

ABSTRACT: In this study, we examine the effect of cranial osteopathic manipulation (COM) on gene expression, in an animal model for age-related cognitive decline (aged rats). We found that COM significantly affected the expression of 36 genes in the neuronal pathway (False Discovery Rate (FDR) < 0.004). The top five neuronal genes with the largest fold-change (Slc5a7, Chat, Slc18a3, Adcy5 and Cacna2d2, >2-fold change, FDR<0.004) are part of the cholinergic neurotransmission mechanism, which is known to affect cognitive function.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE157736 | GEO | 2020/09/10

REPOSITORIES: GEO

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