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IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function

ABSTRACT: In the present study we investigate the role of IL-4 receptor a subunit in intestinal inflammation using DSS-induced colitis model. Our finding suggest that IL-4Ra deficiency enhances intestinal mucosal barrier function through the upregulation of NOX1-dependent ROS production, thereby suppressing the development of intestinal inflammation.

ORGANISM(S): Mus musculus

PROVIDER: GSE157754 | GEO | 2020/09/10

REPOSITORIES: GEO

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IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function

Project description:IL-4 Receptor a Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo through the Enhancement of Intestinal Mucosal Barrier Function

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Interleukin-4 Receptor α Subunit Deficiency Alleviates Murine Intestinal Inflammation In Vivo Through the Enhancement of Intestinal Mucosal Barrier Function.

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