NOX1 is essential for TNFα-induced intestinal epithelial ROS secretion and inhibits M cell differentiation [scRNA-seq]
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ABSTRACT: Loss-of-function mutations of NOX1 is associated with inflammatory bowel disease (IBD). Mechanisms whereby loss of Nox1 drives IBD are incompletely defined. Here we used TNF⍺ treated colonoids to model IBD inflammation followed by single cell sequencing to get transcriptome profile of IBD relevant cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE202675 | GEO | 2022/12/27
REPOSITORIES: GEO
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