Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE158038 | GEO | 2021/02/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Bronchoalveolar lavage)

Project description:Single cell transcriptome, TCR and BCR sequencing of FACS-sorted CD45+ cells of the bronchoalveolar lavages of COVID-19 ICU patients

2021-02-09 | GSE158037 | GEO

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Measles-reactive T cells)

Project description:Single cell transcriptome and TCR sequencing of FACS-sorted Measles-reactive memory T cells of the peripheral blood of a healthy donor

2021-02-09 | GSE158036 | GEO

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, Set 2)

Project description:Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls

2021-02-09 | GSE158034 | GEO

In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1)

Project description:Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls

2021-02-09 | GSE158030 | GEO

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.

Project description:The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care. Before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature; however, following seroconversion, plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-β, and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19 patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction by TGF-β. Despite their continued presence in the blood, plasmablasts are not found in the lungs of deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens of SARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers a chronic immune reaction that is instructed by TGF-β, and is distracted from itself.

| S-EPMC8010106 | biostudies-literature