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Transcriptomic analysis of the major regulator of virulence CovR in Group B Streptococcus strains BM110 and NEM16.

ABSTRACT: To define the transcriptional response associated to a CovR inactivation we performed RNA-Seq in GBS strains BM110 and NEM316. We used mutants in which CovR is inactivated following a two base-pairs chromosomal substitution (AT->CC) resulting in the translation of a CovRD53A variant unable to be phosphorylated by the histidine kinase CovS. We also used a ∆covR mutant in strain BM110 in which the covR sequence is deleted from the chromosome.

ORGANISM(S): Streptococcus agalactiae

PROVIDER: GSE158047 | GEO | 2021/08/23

REPOSITORIES: GEO

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CovS Inactivation Reduces CovR Promoter Binding at Diverse Virulence Factor Encoding Genes in Group A Streptococcus

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