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Src kinase Induces Tumor Formation in the cSRC C57BL/6 Mouse

ABSTRACT: We developed the c-SRC transgenic mouse in the C57BL/6 strain to address the issue of carcinogenesis in cells with high levels of Src expression. The transgene was constructed with the human c-SRC gene downstream of the mouse metallothionein promoter to create zinc inducible gene expression. In these C57BL/6 mice, Src protein was increased in a number of tissues both with and without zinc induction, but most highly in the liver.

ORGANISM(S): Mus musculus

PROVIDER: GSE15815 | GEO | 2009/05/08

SECONDARY ACCESSION(S): PRJNA116731

REPOSITORIES: GEO

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