Genomics

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Identification of noncoding RNA expression profiles following traumatic spinal cord injury by high-throughput sequence analysis


ABSTRACT: To systematically profile and characterize the noncoding RNA (ncRNA) expression pattern in the lesion epicenter of spinal tissues after traumatic spinal cord injury (TSCI). We used RNA-Seq to profle the expression and regulation patterns of noncoding RNAs and mRNAs of mice models after TSCI. A total of 498 circRNAs and 1203 mRNAs were identified in TSCI mice models to be differentially expressed. noncoding RNAs might play important roles via the competing endogenous RNA regulation pattern after TSCI, further findings arising from this study will not only expand the understanding of potential ncRNA biomarkers but also help guide therapeutic strategies for TSCI.

ORGANISM(S): Mus musculus

PROVIDER: GSE158193 | GEO | 2021/10/27

REPOSITORIES: GEO

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